![]() ![]() Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. It is a bone morphogenetic protein receptor, type 1.Īctivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta ( TGF beta) superfamily of structurally related signaling proteins. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, a disease characterized by the formation of heterotopic bone throughout the body. This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. ACVR1 has been linked to the 2q23-24 region of the genome. positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formationĪctivin A receptor, type I ( ACVR1) is a protein which in humans is encoded by the ACVR1 gene also known as ALK-2 ( activin receptor- like kinase-2).BMP signaling pathway involved in heart development.positive regulation of transcription by RNA polymerase II.positive regulation of pathway-restricted SMAD protein phosphorylation.transforming growth factor beta receptor signaling pathway.negative regulation of signal transduction.branching involved in blood vessel morphogenesis.transmembrane receptor protein serine/threonine kinase signaling pathway.positive regulation of osteoblast differentiation. ![]()
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